Cysteinyl leukotrienes in asthma: current state of therapeutic evaluation.
نویسندگان
چکیده
منابع مشابه
Adipokines and Cysteinyl Leukotrienes in the Pathogenesis of Asthma
Background. The prevalence of obesity has increased dramatically over the last decades, and its association with asthma is being increasingly recognized. Aims. Our hypothesis is that increased leptin and decreased adiponectin levels in obese subjects play a direct role in regulating inflammation in asthmatics. We wanted to examine the hypothesis that cysteinyl leukotrienes (cys-LT), inflammator...
متن کاملRole of cysteinyl-leukotrienes in the pathogenesis of nasal polyposis in patients with asthma
Cysteinyl leukotrienes (CysLTs: leukotrienes C4, D4, and E4) have long been implicated in the pathogenesis of allergic diseases such as asthma. CysLTs are potent bronchoconstrictors that have the additional effects of edema, mucous secretion, and eosinophilic accumulation, and airway remodeling. LTE4 has been identified as a major metabolite of LTC4, and urinary LTE4 (U-LTE4) is considered as t...
متن کاملPathophysiology of the cysteinyl leukotrienes and effects of leukotriene receptor antagonists in asthma.
Cysteinyl leukotrienes, synthesized de novo from cell membrane phospholipids, are proinflammatory mediators that play an important role in the pathophysiology of asthma. These mediators are among the most potent of bronchoconstrictors and cause vasodilation, increased microvascular permeability, exudation of macromolecules and edema. The cysteinyl leukotrienes also have potent chemoattractant p...
متن کاملCysteinyl-leukotrienes in the regulation of β2-adrenoceptor function: an in vitro model of asthma
BACKGROUND The response to beta2-adrenoceptor agonists is reduced in asthmatic airways. This desensitization may be in part due to inflammatory mediators and may involve cysteinyl-leukotrienes (cysteinyl-LTs). Cysteinyl-LTs are pivotal inflammatory mediators that play important roles in the pathophysiology of asthma, allergic rhinitis, and other inflammatory conditions. We tested the hypothesis...
متن کاملCysteinyl leukotrienes and 8-isoprostane in exhaled breath condensate of children with asthma exacerbations.
BACKGROUND Cysteinyl leukotrienes (Cys-LTs) and isoprostanes are inflammatory metabolites derived from arachidonic acid whose levels are increased in the airways of asthmatic patients. Isoprostanes are relatively stable and specific for lipid peroxidation, which makes them potentially reliable biomarkers for oxidative stress. A study was undertaken to evaluate the effect of a course of oral ste...
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ژورنال
عنوان ژورنال: Thorax
سال: 1995
ISSN: 0040-6376
DOI: 10.1136/thx.50.9.1005